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Zoloft is an antidepressant, a specific serotonin re-uptake inhibitor, strengthens its effects, has light influence on the reverse re-uptake of norepinephrine and dopamine; in therapeutic doses blocks serotonin re-uptake into human platelets. Suppression of activity of the serotonin re-uptake increases serotonergic transfer, which leads to the subsequent inhibition of adrenergic activity in the locus ceruleus. Sertraline inhibits the excitement serotonin neurons in the field of a seam (the middle line of medulla oblongata), which leads to an initial increase in the activity of locus ceruleus, with a consequent reduction postsynaptic activity of beta-adrenoreceptors and presynaptic alpha 2-adrenergic receptors. The medicine does not cause drug dependence, does not provide psycho-stimulating, sedative, m-choline blocking and cardiotoxic actions, and does not change the psycho-motor activity. Thanks to selective serotonin re-uptake inhibition the drug does not potentiate the activity of the sympathetic nervous system. In contrast to the tricyclic antidepressants in treating depression or obsessive-compulsive disorders (impulsive obsession), the drug does not increase the body weight. The initial effect develops in the period of 7 days, a full - within 2-4 weeks. So, you can order generic Zoloft online without a prescription in our drug store.

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