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Diazepam (Valium) is a tranquilizer, benzodiazepine derivative, which has anxiolytic, sedative, anticonvulsant, and central myorelaxing action. Indications to the drug application: neuroses, psychopathy, schizophrenia, and insomnia, epilepsy, and itching dermatosis. Contraindications: severe myasthenia gravis, severe chronic hypercapnia; alcohol or drug dependence in the history (except for acute withdrawal); hypersensitivity to Diazepam and other benzodiazepines, and pregnancy. Here you can purchase brand Valium online no Rx.

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Valium is a tranquilizer, benzodiazepine derivative, has anxiolytic, sedative, anticonvulsive, and central muscle relaxing effects. The mechanism of its action is associated with increased braking power GABA in the CNS. Muscle relaxing effect is due to the inhibition of the spinal reflexes. The drug can cause anticholinergic effect.

Pharmacokinetics

The drug absorption is rapid. The maximal concentration in plasma is observed 90 minutes after its taking. Linking plasma protein is 98%. Diazepam penetrates through the placental barrier, into the cerebrospinal fluid and can penetrate into the breast milk, metabolized in the liver, excreted by kidneys (70%).

Dosage

Valium is taken orally, intramuscularly, intravenously, and rectally. A daily dose varies from 500 mcg up to 60 mg. A single dose, frequency and the duration of application should be set individually.

Pregnancy and lactation

You shouldn’t take Diazepam in the first trimester of pregnancy, except in cases of extreme necessity. You should take into account that Valium using in pregnancy may cause significant changes of the fetus heart rate.

Using in obstetrics doses is recommended for ease childbirth, newborn, often in premature infants: temporary muscle hypotension, hypothermia, and respiratory failure are possible.

Breastfeeding should be discontinued in the regularly drug taking.

Avoid Diazepam using for newborns, as they haven’t formed enzyme system, participated in the metabolism. Here you can order brand Valium online without a prescription.

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