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Lanoxin is a cardiotonic remedy - cardiac glycoside. It blocks the transport of Na+/K+-adenosinetriphosphatase, resulting in increased content of Na+ in cardiac hystiocyte, which leads to the opening of the Ca2+-channels and the occurrence of Ca2+ in cardiomyocytes. In addition, an excess of Na+ leads to the acceleration of the allocation of Ca2+ from the sarcoplasmic reticulum. The concentration of Ca2+ increases, which leads to troponin complex inhibition, providing a depressing effect on the interaction of actin and myosin. Increased strength and speed of the heart muscle contraction occurs according to the mechanism, which is different from the mechanism of the Frank-Starling (not depends on the degree of myocardium pre-stretch). Systola becomes shorter and energetically economical. Lanoxin reduces endsystolic and, of course, diastolic ventricle of the heart volumes, that, along with the increased tone of the myocardium, leads to a reduction in its size and, thus, to reduce the heart need in oxygen. Negative dromotropic action is manifested in adiaphoria of AV node increasing that allows using the drug in supraventricular tachycardia paroxysms and tachyarrhythmias. We offer the cheapest Lanoxin for sale online with free shipping.

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