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Lamictal is an anticonvulsant drug; it blocks voltage-sensitive sodium channels, stabilizes membranes of neurons and inhibits the release of glutamic acid, which plays a key role in triggering seizures.

Lamictal is rapidly and completely absorbed from the intestine. Cmax plasma is approximately 2.5 hours after receiving inside. Tmax is increased slightly after a meal, but the level of absorption remains unchanged.

Pharmacokinetics has linear character when the drug administered in the dose of 450 mg. The degree of Lamotrigine binding with plasma protein is about 55%. The volume of distribution is 0.92-1.22 l/kg. In adults Lamotrigine Cl averages 39±14 ml/minute. Lamictal is metabolized to glucuronids, which are excreted with urine. Less than 10% of the drug excreted with the urine unchanged, and about 2% with faeces. Clearance and T1/2 is not dependent on a dose. Lamotrigine Cl is calculated by body mass index, higher in children than in adults; it is the highest among children under 5 years old. In children lamotrigine T1/2 is usually shorter than in adults.

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