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Colchicine is a drug, derived from the meadow saffron Crocus (Colchicum autumnale); is used to reduce pain in acute gouty attack, for the prevention of relapse of acute gouty attack, especially in the first 2 years after the beginning of reception hypouricemic remedies, systemic scleroderma, amyloidosis, Behcet's Disease, familial Mediterranean fever, as well as to prevent polyserositis attacks.

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The drug should be taken inside; possible side effects: nausea, vomiting, diarrhea, and stomach pain.

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Colchicine is used for reducing an acute attack of gout, as well as in familial Mediterranean fever, Behcet's disease, and chondrocalcinosis.

Way of application and dosage: tablets or pills should be swallowed a whole, not chewing, squeezed enough liquid.

In an acute attack of gout Colchicine should be taken the first 1 mg, and then 0.5-1.5 mg every 1-2 hours prior to the weakening of the pain. The total dose, adopted by the day, should not exceed 8 mg.

Colchicine side effects: nausea, vomiting, pain in the abdomen, diarrhea, depression, peripheral neuritis, neuropathy.

Contraindications: hypersensitivity, pregnancy, severe hepatic and/or renal insufficiency, severe violations of the gastrointestinal tract, bone marrow, purulent infection, alcoholism, and old age.

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